As bonus to Episode 33 on oncologic emergencies, Dr. John Foote, the CCFP(EM) residency program director at the University of Toronto tells us about his Best Case Ever in which he missed an important cancer-related diagnosis. In the related episode with Dr. Foote and Dr. Joel Yaphe, we will review 5 common presentations in the patient with cancer: fever, shortness of breath, altered mental status, back pain and acute renal failure; with specific attention to key cancer-related emergencies such as febrile neutropenia, hypercalcemia, superior vena cava syndrome, hyperviscosity syndrome and tumor lysis syndrome.