Step 1: Distinguish Pediatric Seizures vs. Pediatric Seizure mimics
Much of the distinction between true pediatric seizures and mimics will hinge on elements gathered from the history. Ask about the onset, duration, nature of the movements, tongue biting, eye findings and details of the recovery phase. A history of incontinence can be helpful in older children who are no longer in diapers. The presence or absence of an aura will only be helpful in children who are able to provide a clear account of their experience. Be sure to ask the parents what the eyes, neck and head were doing at the time of the seizure. The recovery phase is also important since a rapid return to normal activity speaks against a true seizure.
Elements that are highly suggestive of true seizure activity include:
- Lateralized tongue-biting (high specificity)
- Flickering eye-lids
- Dilated pupils with blank stare
- Lip smacking
- Increased heart rate and blood pressure during event
- Post-ictal phase
Distinguishing Breath-holding spells from Pediatric Seizure
Breath holding spells are most common in the 6-18month age range. One of the key differentiating factors is that there is usually a clear trigger for a breath holding spells such as emotional distress or pain, whereas seizures typically do not have such precipitants. This pattern of an initiating trigger, followed by emotional upset, crying, pallor, and occasionally LOC is highly suggestive of a breath holding spell. The breath holding and LOC can lead to brief seizure activity given the decrease cerebral blood-flow. However, the recovery from a breath-holding spell is rapid and complete without a post-ictal phase.
Distinguishing Pseudo-Seizures from True Seizure
These tend to be seen in the adolescent population since younger children cannot feign seizure activity for secondary gain. Features that distinguish these events from true seizures include side-to side head, arm or leg movements with eyes closed. If the eyes are open, the eye movements are normal as opposed to deviated. A bicycling movement of the legs is highly suggestive of pseudo-seizure.
Distinguishing Syncope from Seizure
Syncopal episodes may or may not have a clear precipitant but the LOC always precedes any perceived seizure activity. Observers may note some brief twitching episodes as opposed to true tonic-clonic movements. The recovery from a syncopal episode is rapid and complete.
Step 2: Distinguish Simple vs. Complex Febrile Seizure
Once you have established that the child did in fact have true seizure activity in the context of a fever, the next step is to clearly define whether it fits the pattern of a simple or a complex febrile seizure. A diagnosis of complex febrile seizures is made if there is any deviation from the criteria of a simple febrile seizure. This distinction is important because complex seizures may indicate a more serious disease process and usually require a work-up.
Simple febrile seizures tend to occur early in the illness within 24hrs of onset of fever –
if the seizure occurs >24hrs after the onset of fever, the suspicion for a bacterial cause of the fever
and a pathologic cause for the seizure should be heightened.
Which Patients with Febrile Seizures Require a Work-up?
If the child meets the criteria for a simple febrile seizure, no dedicated seizure workup is required and you evaluate the patient as if they solely had a fever. It is clear in the literature that children who have suffered a simple febrile seizure are at no greater risk for serious bacterial infection than age-matched controls who have not seized. A child who fits the criteria for a simple febrile seizure should be worked up as if they presented with fever and no seizure. Studies have shown that measurement of serum electrolytes or glucose in particular has no role in the workup of simple febrile seizures. A workup beyond a basic febrile workup should be considered if the child appears unwell or meets any of the criteria of a complex febrile seizure.
Our experts recommend the workup of complex febrile seizures to be a step wise approach, keeping in mind that the younger the child the more aggressive the work-up should be. Children who return to baseline after a complex seizure and at no point displayed any focal neurologic symptoms usually do not require an extensive work-up. Even though studies have shown that febrile seizures do not increase the risk of serious bacterial infection compared to fever alone, meningitis should always be on the differential diagnosis in a child with complex febrile seizures. About 25 % of children with meningitis will present with a new onset febrile seizure, however they will almost always display persistent mental status abnormalities along with other signs of meningitis such as nuchal rigidity, focal siezures and petechia.
Update 2018: A retrospective study including over 28,000 patients (ages 0-5) with complex febrile seizures showed a very low incidence of CNS infections, suggesting lumbar punctures are low-yield in this population. Caution was warranted in those who are unvaccinated, pre-treated with anti-biotics or had suspicious symptoms/signs of CNS infection. Abstract
Counseling Parents about Pediatriac Seizures
Safety – place the child in the recovery position and do not place anything in the child mouth
Risk of recurrence is approximately 33% overall with a higher risk in children
- temperature < 40.0°C at first convulsion
- family history of febrile seizures
If they have all 4 of the factors, their risk of recurrence is 70%. If they don’t meet any criteria, their risk falls to 20%.
Risk of Epilepsy is approximately 2% after a simple febrile seizure and 5 % after a complex febrile seizure (compared to 1% in the general population)
Parents will often blame themselves for not treating the seizure appropriately or quickly enough to prevent the seizure. It is important to educate them that the height of the fever or rapidity of onset does not predict risk of suffering a seizure and that prophylactic antipyretics do not decrease the rate of seizure recurrence.
Non-febrile Pediatric Seizures
The differential diagnosis of non-febrile pediatric seizures is extensive, encompassing metabolic derangements to mass lesions to non-accidental trauma.
Hyponatremia secondary to over-dilution of infant formula
One particular diagnosis that is one of the more common causes of non-febrile seizure in children under 6months of age and that is relatively easy to pick up thus avoiding an extensive invasive work-up is hyponatremia secondary to formula over-dilution. In a paper from the Annals of EM, hyponatremia was the cause of seizures in 70% of 47 infants younger than 6 months who lacked other findings suggesting a cause. They found that a temperature of 36.5°C or less as the best predictor of hyponatremic seizures.
If a pediatric patient with hyponatremia as a cause for their seizures seizes in the ED, they should be treated with 3cc/kg of hypertonic (3%) normal saline.
Physical Examination Pearls for Non-febrile Pediatric Seizures
Looking for the following signs can help in the workup of a non-febrile seizure:
Skin Look for lesions such as cafe au lait spots (neurofibromatosis), adenoma sebaceum or ash leaf spots (tuberous sclerosis), and port wine stains (Sturge-Weber syndrome). Unexplained bruising should raise the suspicion of a bleeding disorder or child abuse.
Head Examine for bulging fontanelle, microcephaly, dysmorphic features, signs of trauma, presence of a VP shunt.
Eyes Examine for papilledema and retinal hemorrhages
Neck Examine for signs of meningeal irritation.
Hepatosplenomegaly May indicate a metabolic or glycogen storage disease.
In patients who have no identifiable risk factors, an accurate and thorough history and physical examination
have been shown to yield more diagnostic information than a laboratory evaluation.
Work-up of Non-febrile Pediatric Seizures
Lab tests may not be necessary in a child who is alert and has returned to a baseline level of function and should be based on clinical suspicion.
Consider ordering laboratory studies on pediatric patients who:
- Have prolonged seizures,
- < 6 months of age (specifically for hyponatremia)
- History of diabetes, metabolic disorder, dehydration, or excess free water intake
- Altered LOC
Update 2015: Study finds that age < 2, first time seizure and seizure in the ED are characteristics which show a trend towards increased yield of blood work and CT head. Abstract
What is the role of a CT head in the work up of non-febrile pediatric seizures?
For non-febrile seizures, emergent neuroimaging is not necessary in children who have suffered their first non-febrile seizure and have returned to their baseline.
High risk factors on history of physical exam that should prompt consideration of neuroimaging include:
- Focal seizure or persistent seizure activity
- Focal neurologic deficit
- VP shunt
- Neurocutaneous disorder
- Signs of elevated ICP and history of trauma or travel to an area endemic for cysticercosis.
- Patients who have immunocompromising diseases (malignancy or HIV),
- Hypercoagulable states (sickle cell disease), or bleeding disorders
Disposition of Patients with Non-febrile Pediatric Seizures
Disposition of non-febrile seizures depends on age, serial physical examinations, initial work-up and follow-up capabilities
Under 6months of age – generally require a full workup and are usually admitted for observation.
6 months and 2 years of age – disposition will depend on blood work, reassessment and the ability to have close follow-up.
Over 2 years of age – those who have returned to baseline, have a normal neurological exam with normal workup are often safe to be discharged to close outpatient follow-up. Otherwise, admit.
Parents should be informed that approximately 50% of children who have a non-febrile seizure will have a recurrence.
Status Epilepticus in Emergency Management of Pediatric Seizures
Status Epilepticus (SE) was historically defined as any seizure activity lasting longer than 30mins, but this has changed in recent years. Given that we strive to terminate seizure activity long before 30min, SE is now more conservatively defined as a:
- Seizure lasting > 5 minutes, OR
- Consecutive seizures without a return to baseline in between
When you are faced with a seizing child, the priorities are the same as with any resuscitation: ABCs. Start by evaluating the airway and provide supplemental oxygen, then establish cardiac monitoring. The next steps will focus on terminating the seizure and the goal is to terminate all seizure activity within 60 seconds.
Administration of EARLY benzodiazepines is a priority!
In an actively seizing child, IV and IO access may be difficult and time-consuming. For your first dose of benzodiazepines, consider either intranasal, buccal, intramuscular or rectal dosing of the following medications:
The choice of benzodiazepine and the choice of route is not the major determinant of efficacy.
Rather, the most important determinant of benzodiazepine efficacy in stopping seizures is
time to administration.
There have been many studies evaluating the different benzodiazepines and routes of administration. For example, in a pre-hospital setting, intramuscular midazolam was shown to be as effective at terminating seizures as intravenous lorazepam. In another randomized trial, buccal midazolam was superior to rectal diazepam at stopping seizure activity.
Update 2017: This systematic review of 11 studies found non-IV benzodiazepines (NIVB) were able to be given more quickly than IV benzodiazepines and stopped seizure activity >3 minutes sooner. NIVB were given by rectal, buccal, intranasal, or IM route. Abstract
Clinical Pearl: Once you have started giving your antiepileptic medications start drawing up the next dose of medication so that it is ready to administer if seizure activity continues to persist.
Pediatric Status Epilepticus Algorithm
Second Line Agents in Status Epilepticus – Phenytoin vs. Fosphenytoin
Phenytoin and fosphenytoin are the same active medication. The difference between the two preparations lies in the side effect profile and the manner in which it can be administered. For these reasons fosphenytoin is the preferred second line agent for treatment of SE.
Phenytoin and fosphenytoin are less effective for the treatment of seizures due to toxins or drugs and may intensify seizures caused by cocaine, other local anesthetics, theophylline, or lindane. In such cases, an alternative second-line drug such as phenobarbital or valproate should be used.
Update 2019: Two multicentre, randomized controlled trials (EcLiPSE and ConSEPT) involving emergency treatment of pediatric convulsive status epilepticus compared second line agents levetiracetam to phenytoin, and showed levetiracetam was not superior to phenytoin. Abstract-EcLIPSE Abstract-ConSEPT
Refractory Status Epilepticus
If, despite all the medications and efforts described above, your patients is still seizing, initiate continuous IV infusions of:
- Midazolam (120mcg/kg/hr and titrate upwards)
- Propofol (contraindicated with ketogenic diet)
- Ketamine -a recent systematic review indicates 63.5% cessation rates in seizures in pediatric refractory status epilepticus, however our experts do not recommend it as a first line agent in this setting
For more EM Cases content on Pediatric Emergencies check out our free interactive eBook,
EM Cases Digest Vol. 2 Pediatric Emergencies here.
For more Pediatric EM learning visit one of EM Cases collaborators trekk.ca – Translating Emergency Knowledge for Kids (TREKK) is a growing network of researchers, clinicians, health consumers and national organizations who want to accelerate the speed at which the latest knowledge in children’s emergency care is put into practice in general EDs – rural, remote or urban.
Patel N, Ram D, Swiderska N, Mewasingh LD, Newton RW, Offringa M. Febrile seizures. BMJ. 2015;351:h4240.
Berg AT, Shinnar S, Darefsky AS, et al. Predictors of recurrent febrile seizures. A prospective cohort study. Arch Pediatr Adolesc Med. 1997;151(4):371-8.
Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med. 1976;295(19):1029-33.
Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics. 2011;127(2):389-94. Full PDF
Farrar HC, Chande VT, Fitzpatrick DF, Shema SJ. Hyponatremia as the cause of seizures in infants: a retrospective analysis of incidence, severity, and clinical predictors. Ann Emerg Med. 1995;26(1):42-8. Full PDF
Warden CR, Brownstein DR, Del beccaro MA. Predictors of abnormal findings of computed tomography of the head in pediatric patients presenting with seizures. Ann Emerg Med. 1997;29(4):518-23.
Hirtz D, Berg A, Bettis D, et al. Practice parameter: treatment of the child with a first unprovoked seizure: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2003;60(2):166-75. Full PDF
Alford EL, Wheless JW, Phelps SJ. Treatment of Generalized Convulsive Status Epilepticus in Pediatric Patients. J Pediatr Pharmacol Ther. 2015;20(4):260-89.
Welch RD, Nicholas K, Durkalski-mauldin VL, et al. Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia. 2015;56(2):254-62.
Mcintyre J, Robertson S, Norris E, et al. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 2005;366(9481):205-10.
Chin RF, Neville BG, Peckham C, Wade A, Bedford H, Scott RC. Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study. Lancet Neurol. 2008;7(8):696-703.
Shearer P, Park D. Seizures and Status Epilepticus: Diagnosis and Management in the Emergency Department. Emergency Medicine Practice. 2006; 8 (8). Full PDF
Zeiler FA. Early Use of the NMDA Receptor Antagonist Ketamine in Refractory and Superrefractory Status Epilepticus. Crit Care Res Pract. 2015;2015:831260.
Other FOAMed Resources on Pediatric Seizure
Pediatric seizure mimics on Pediatric EM Morsels
Management of adult status epilepticus on First10EM
Dr. Helman, Dr. Mikrogianakis & Dr. Richer have no conflicts of interest to declare
For more EM Cases content on Pediatric Emergencies check out our free interactive eBook,
EM Cases Digest Vol. 2 Pediatric Emergencies here.