A lot has changed over the years when it comes to managing the adult in cardiac arrest. As a result, survival rates after cardiac arrest have risen steadily over the last decade. With the release of the American Heart Association ACLS Guidelines 2015 online on Oct 16th, while there aren’t a lot a big changes, there are many small but important changes we need to be aware of, and there still remains a lot of controversy. In light of knowing how to provide optimal cardio-cerebral resuscitation and improving patient outcomes, in this episode we’ll ask two Canadian co-authors of The Guidelines, Dr. Laurie Morrison and Dr. Steve Lin some of the most practice-changing and controversial questions.
In Part 1 of ACLS Guidelines 2015 – Cardiac Arrest Controversies we discuss the science and controversies around the following questions: What exactly determines ‘high quality CPR’ and how can we best achieve it? How do we best assess cardiac output during our resuscitation? How and when should we be giving epinephrine or vasopressin in the cardiac arrest patient? What’s the best way to manage refractory Ventricular Fibrillation? How soon do we need to intubate in cardiac arrest? and many more…
When you’re finished Part 1 Go HERE for Part 2 of this series on ACLS Guidelines 2015 Controversies: Post Arrest Care with a special guest appearance by Scott Weingart
Written Summary and blog post prepared by Dr. Anton Helman, October 2015
Cite this podcast as: Helman, A, Morrison, L, Lin, S. ACLS Guidelines 2015 – Cardiac Arrest Controversies Part 1. Emergency Medicine Cases. October, 2015. https://emergencymedicinecases.com/acls-guidelines-2015-cardiac-arrest/. Accessed [date].
Quick List – ACLS Guidelines 2015 for Cardiac Arrest Update
The recommended chest compression rate is 100-120 per minute which is updated from the at least 100/min.
The recommended chest compression depth is 5-6cm or just over 2 inches, but not more than 6cm as too deep can be harmful.
Use Audiovisual devices such as metronomes and compression depth analyzers which can be used to optimize CPR quality.
The routine use of impedence threshold devices (ITDs) alone or mechanical chest compression devices alone are not recommended, however in out of hospital situations where manual compressions are difficult due to physical space limitations, mechanical devices may be useful.
A recent RCT suggests that the use of the ITD plus active compression decompression CPR is associated with improved neurological intact survival for patients with out of hospital cardiac arrest.
ECMO or ECPR may be considered for selected patients with refractory cardiac arrest where a reversible cause of cardiac arrest is suspected.
Vasopressin has been removed from the algorithm altogether, and an emphasis on EARLY administration of epinephrine is stressed.
Ultrasound has been added as an additional method for helping to confirm ROSC and for confirming ETT placement.
Use maximum inspired oxygen during CPR and then after ROSC, titrate oxygen to an oxygen saturation of 94% rather than continuing maximum oxygen delivery.
A low end tidal CO2 in intubated patients after 20 minutes of CPR is associated with a very low likelihood of survival, and this factor should be used in combination with other factors to help determine when to terminate resuscitation.
The routine use of lidocaine after ROSC is not recommended, however the initiation or continuation of lidocaine may be considered immediately after ROSC from ventricular fibrillation or pulseless ventricular tachycardia.
Emergency PCI is recommended for all patients with STEMI AND for hemodynamically or electrically unstable patients without ST elevation for whom a cardiovascular lesion is suspected.
Do Targeted Temperature Management – recommendations have been updated with new evidence suggesting that a range of temperatures between 32 and 36 may be acceptable to target in the post cardiac arrest period, and an emphasis on fever prevention and treatment is stressed.
CCR rather than CPR, CAB rather than ABC
Before we jump into the controversies it’s important to understand the basic theory of how best to achieve meaningful survival in the cardiac arrest patient. The concept of Cardiocerebral Resuscitation rather than Cardiopulmonary Resuscitation emphasizing high quality, minimally‐interrupted chest compressions to maximize blood flow to the brain, an important theoretical determinant of long term survival.
Circulation-Airway-Breathing as opposed to the classic Airway-Breathing-Circulation is how we should approach these patients because of the realization that arterial oxygen saturation remains high for the first 5‐10min of a cardiac arrest, that recoil of the chest during chest compressions improves oxygenation, that delaying a definitive airway increases survival, and that high quality continuous compressions improves survival.
In Toronto, the survival rate overall for cardiac arrest has improved from 2% in 2004 to 13% in 2015, probably related to improved early defibrillation and improved quality of chest compressions. The survival rate for Ventricular Fibrillation in Toronto has risen from 8% in 2004 to 35% in 2015.
Caveat: because children usually die as a result of asphyxia and respiratory complications, early ventilations should be emphasized in the pediatric population.
The recommended rate of chest compressions of 100-120 per minute, aiming for 110 per minute with audiovisual feedback such as a metronome (which is easily activated on most defibrillators), and the recommended depth of compressions is 5-6cm with visual feedback (which is also easily activated on most defibrillators). These recommendations are based on observational studies from the Resuscitation Outcomes Consortium (ROC) papers.
Created by Justin Morgenstern from First10EM
The guidelines suggest a compression to breath ratio of 30:2, however in Seattle, the survival rates for cardiac arrest overall have remained around 19-20%, and for Ventricular Fibrillation are 44%, the highest in the world, possible, in part due to a revision of the compression to breaths ratio. Rather than the recommended 30:2 compressions:breath ratio, in Seattle, the paramedics provide continuous chest compressions. On the 10th compression, the provider handling the breathing gives a single 500cc breath, in between compressions, without any pause in compressions. The only time that Seattle paramedics pause compressions is to shock the patient, and even then, once they have determined that the patient is in ventricular fibrillation, while continuing compressions, they count down out loud and pause compressions for only a single, hands-0ff beat to re-administer a shock every 15 compressions until signs of ROSC are apparent. Experimental data out of England shows that, using gloves, the maximal energy delivered to a provider providing hands-on compressions without any pause for defibrillation is less than the average house hold electrical current, suggesting that hands-on defibrillation may be safe.
In order to minimize compression pauses for pulse checks, our experts recommend two approaches:
1. Have a dedicatedexperienced provider feeling for a manual femoral pulse during chest compressions so that as soon as a pause in chest compressions to assess for cardiac rhythm occurs at the end of 2 minutes of compressions, the pulse can be rapidly assessed along with the cardiac rhythm in less than 5 seconds (as apposed to less than 10 seconds as recommended in the guidelines).
2. Do not check for the pulse at all! Chest compressions should continue until your end tidal CO2 monitor shows persistent elevations. The argument here is that palpating for a pulse has been shown to be insensitive, not specific and have poor inter-rater reliability. One study showed that rescuer pulse palpation was only 78% accurate. Even if a pulse is felt, this does not guarantee adequate perfusion to vital organs. Dr. Morrison suggests stopping chest compressions only to assess for defibrillation and to defibrillate. An alternative to manual pulse checks suggested by Dr. Weingart in Part 2of this series is to establish an early arterial line so that the moment a pause in chest compressions occurs, providers know if there is an increase in arterial pressure.
Update 2015: Trial in NEJM compares continuous vs interrupted chest compressions (30:2) and finds that as long as the chest compression fraction is >75% then there appears to be no difference in survival to hospital discharge. Abstract. Analysis on The Bottom Line.
Update 2018: A meta-analysis of 7 RCTs involving patients undergoing CPR showed manual compression to be more effective and safer than mechanical compression devices (AutoPULSE and LUCAS) with respect to survival at 30 days or hospital discharge, and neurological recovery. Manual compression also reduced risk of pneumothorax or hematoma formation compared to AutoPulse. Abstract
Simulation Training and Cardiac Arrest Teams
Simulation training plays an important role in optimizing performance of cardiac arrest teams. Like NASCAR tire replacement teams, the cardiac arrest team should be proficient at performing their specific dedicated tasks. Observational data from the Resucitation Outcomes Consortium (ROC) show that the larger the cardiac arrest team the better the outcome. Where as previous guidelines focused on developing the skills of the leader of the resuscitation, current trends are to develop skills of each individual on the cardiac arrest team.
The Role of Capnography in Cardiac Arrest
ETCO2 capnography is mandated in the 2015 Guidelines to be used to:
1. Confirm endotracheal intubation with an increase in ETCO2
2. Assess the quality of chest compressions with an ETCO2 goal of 12-15; an ETCO2 of less than 10 may be an indicator of sub-optimal chest compressions
3. An increase of ETCO2 35-40 may indicate adequate tissue oxygenation and can be used to confirm return of spontaneous circulation (ROSC), however our experts recommend continuing CPR after the initial spike of ETCO2.
Pitfall: stopping chest compressions immediately after an ETCO2 of 35-40 is recognized
The Role of Chest Compression Devices in Cardiac Arrest
In multiple randomized control trials mechanical CPR have not shown superiority to good quality manual chest compressions.
The Guidelines recommend considering the use of compression devices in environments where manual compressions may be difficult or impossible due to physical constraints (eg: small cabins of some rescue helicopters). Mechanical CPR should be considered in situations where rescuer fatigue is a concern or prolonged CPR is anticipated, such as in a hypothermic arrest.
Impedance threshold Devices (ITD) are circulatory devices which are applied to the endotracheal tube (ETT) or the bag-valve-mask (BVM) and increase perfusion to the right side of the heart. In a ROC study patients randomized to ITD vs sham ITD showed no superiority of the ITD.
Some experts believe that the reason mechanical CPR devices have not shown superiority is because of inadequate training resulting in long chest compression pauses while placing the machine on the patient and hence decreased perfusion, but with adequate training that minimizes the pause in chest compressions while placing the machine on the patient, they may prove to be clinically superior to manual compressions in achieving ROSC and perhaps long term outcomes.
For a detailed review and demonstration of Mechanical CPR devices watch Dr. Oliver Flower’s talk on Mechanical CPR from SMACC Gold
Antiarrhythmic Medications in Refractory Ventricular Fibrillation
There has never been an antiarrhythmic medication
that has shown any long term survival benefit in cardiac arrest
Amiodarone 300mg IV bolus is still recommended as the antiarhythmic of choice for refractory ventricular fibrillation.
In one study from the 1990’s comparing Amiodarone to placebo in refractory ventricular fibrillation, a higher rate of ROSC was achieved.
In a study from the NEJM out of Toronto, pre-hospital ventricular fibrillation patients were randomized to amdiodarone vs lidocaine, and amidorone showed a higher rate of ROSC compared to lidocaine, however the death rate in hosptial in the amiodarone group was higher than that of the lidocaine group. Overall, survival at discharge from hospital was similar in both groups.
The Amiodarone vs Lidocaine vs Placebo (ALPS) Trial is currently ongoing with a projected release in early 2016.
Update 2018: A systematic review of 14 RCTs and 17 observational studies in adults, and 1 observational study in pediatrics, showed no benefit of anti-arrhythmic drugs during CPR for shockable cardiac arrest with respect to survival at hospital discharge, favourable neurologic function and long-term survival. Lidocaine did show improved ROSC compared to placebo. Abstract
Dual Shock Therapy for Refractory Ventricular Fibrillation
Dual Shock Therapy involves defibrillating patients who are refractory to multiple defibrillations with 2 defibrillators at the same time or within seconds of each other, one with pads set up in the traditional anterior positions and the other set up with anterior-posterior pad positions.
By Charles Bruen from Resus Review
A recent observational case series showed improved rates of ROSC with dual shock therapy with one patient surviving to hospital discharge.
An RCT in 1989 by Bardy randomized patients with refractory ventricular fibrillation to dual vs single shock therapy and found no significant difference in ROSC.
It is unknown based on current evidence whether the improved rates of ROSC with dual shock therapy are due to chance alone or due to the increase in energy or multiple vectors of energy delivered to the heart.
Dual shock therapy for refractory ventricular fibrillation is not recommended in The Guidelines.
Despite the lack of evidence that dual shock therapy improves survival, our experts recommend attempting it when other avenues have been exhausted in the patient with refractory ventricular fibrillation.
Epinephrine and Vasopressin in Cardiac Arrest
There has never been a vasopressor medication
that has shown any long term survival benefit in cardiac arrest
Epinephrine has been shown in RCTs to improve rates of ROSC and admission to hospital, however one large pre-hospital study of Japan, while also showing improved rates of ROSC, showed worse 1 month survival rates with epinephrine.
Update 2018: Among patients who have suffered out of hospital cardiac arrest with a non-shockable initial rhythm, each minute delay in epinephrine administration was associated with decreased survival and unfavorable neurological outcomes. Abstract
Update 2018: PARAMEDIC2 trial. A randomized double-blind controlled trial involving 8014 patients with out of hospital cardiac arrest (OHCA), demonstrated improved 30-day survival with epinephrine versus placebo, but had poorer neurologic outcomes at discharge and at 30 days. Abstract.
Optimizing Epinephrine in Cardiac Arrest
Multiple factors may contribute to the effectiveness of epinephrine in cardiac arrest:
Dose and frequency of administration
Underlying rhythm and suspected diagnosis
The Guidelines recommend administering epinephrine as early as possible in the resuscitation.
Observational data suggests that the first dose of epinephrine is administered at 22 minutes on average after cardiac arrest. Some experts believe that earlier administration in the first 4 minutes during the ‘circulatory phase’ of cardiac arrest may improve long term outcomes, but there is only observational data for this in the literature.
One observational study of cardiac arrest with non-shockable rhythm compared epinephrine given at 1 to 3 minutes with epinephrine given at 3 later time intervals (4 to 6, 7 to 9, and greater than 9 minutes). The study found an association between early administration of epinephrine and increased ROSC, survival to hospital discharge, and neurologically intact survival.
Dose and Frequency of Administration
Some experts believe that the dose of 1mg every 3-5 minutes that is recommended in the guidelines is too high a dose, is too frequently given and may be detrimental. Epinephrine, in the doses used in cardiac arrest, causes cerebral vasoconstriction that may impair tissue oxygenation, brain perfusion and compromise neurological recovery.
Scott Weingart describes titrating epinephrine in cardiac arrest to hemodynamic parameters and end tidal CO2 in this EMCrit podcast, and in Part 2 of this podcast. Titrating to diastolic BP, as described in the Paradis study in JAMA requires early placement of an arterial line during ongoing chest compressions. While end tidal CO2 is an excellent marker for chest compression quality and determining ROSC, titrating epinephrine to end tidal CO2 goals have never been shown to be associated with long term outcomes.
A physiologic measure of brain oxygenation measured by near-infrared spectroscopy may be a better marker to titrate epinephrine to in cardiac arrest, but currently there is no evidence in the literature to support its use.
Underlying rhythm and suspected diagnosis
In most patients in ventricular fibrillation the primary cause is an MI. Some experts believe that we should lower the dose of epinephrine in patients with ventricular fibrillation as a the primary rhythm during cardiac arrest to minimize the vasoconstriction of the coronary arteries caused by epinephrine given at 1mg every 3-5 minutes.
In patients with non-shockable rhythms (PEA, asystole), early administration of epinephrine may be more beneficial than in patients’ whose presenting rhythm is ventricular fibrillation.
Epinephrine vs Vasopressin in ACLS Guidelines 2015 – Cardiac Arrest
Vasopressin is difficult to draw up compared to the pre-filled epinephrine syringes and has not been shown to be superior to epinephrine in terms of survival benefit in cardiac arrest patients for out of hospital cardiac arrest. It has therefore been removed from The Guidelines.
The Guidelines do state that vasopressin may provide some benefit when administered with steroids and epinephrine in treating in-hospital cardiac arrests. However, routine use of this bundle is not recommended. This was based on a controversial study in 2013 out of JAMA in Greece with 268 patients which showed that the combination of vasopressin, epinephrine and steroids significantly improved survival to discharge with good neurological outcome compared to only epinephrine and placebo. However, our experts suggest that due to methodological flaws in the study, they cannot recommend it’s routine use as per The Guidelines.
Go HEREfor Part 2 of this series on ACLS Guidelines 2015 Controversies: Post Arrest Care
Kudenchuk PJ, Brown SP, Daya M, et al. Resuscitation Outcomes Consortium-Amiodarone, Lidocaine or Placebo Study (ROC-ALPS): Rationale and methodology behind an out-of-hospital cardiac arrest antiarrhythmic drug trial. Am Heart J. 2014;167(5):653-9.e4.
Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med. 2002;346(12):884-90.
Bardy GH, Ivey TD, Allen MD, Johnson G, Greene HL. Prospective comparison of sequential pulse and single pulse defibrillation with use of two different clinically available systems. J Am Coll Cardiol. 1989;14(1):165-71.
Eckstein M, Hatch L, Malleck J, Mcclung C, Henderson SO. End-tidal CO2 as a predictor of survival in out-of-hospital cardiac arrest. Prehosp Disaster Med. 2011;26(3):148-50.
Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S. Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA. 2012;307(11):1161-8.
Paradis, N, Coronary Perfusion Pressure and the Return of Spontaneous Circulation in Human Cardiopulmonary Resuscitation. JAMA. American Medical Association (AMA), 1990; February 23.
Murkin JM, Arango M. Near-infrared spectroscopy as an index of brain and tissue oxygenation. Br J Anaesth. 2009;103 Suppl 1:i3-13.
Mentzelopoulos SD, Malachias S, Chamos C, et al. Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial. JAMA. 2013;310(3):270-9.
Dr. Helman, Dr. Morrison & Dr. Lin have no conflicts of interest to declare
Dr. Anton Helman is an Emergency Physician at North York General in Toronto. He is an Assistant Professor at the University of Toronto, Division of Emergency Medicine and the Education Innovation Lead at the Schwartz-Reisman Emergency Medicine Instititute. He is the founder, editor-in-chief and host of Emergency Medicine Cases.