This is EM Cases Episode 128 Low Risk Chest Pain and High Sensitivity Troponin – A Paradigm Shift
Talk to any emergency doctor worth their salt, and they’ll tell you that it isn’t the wildly sick patients who keep them up at night – it’s the ones they sent home. Every disease has high risk and low risk populations, and every patient has diseases they are individually more or less likely to have. It’s a battle of odds, and the stakes couldn’t be higher. So fittingly, chest pain is a high risk topic, but has low risk patients that we need to identify accurately in the ED. In this podcast with Dr. Eddy Lang and world expert on troponin researcher Dr. Andrew McRae, we answer the not-so-simple questions: In the age of high sensitivity troponins and the HEART pathway, which low risk chest pain patients are safe to discharge home from the ED? What are the most useful historical factors to increase and decrease your pretest probability for ACS? Which cardiac risk factors have predictive value for ACS? Why should the words “troponitis” and “troponemia” be banned? How should high sensitivity troponin be interpreted differently than conventional troponin? Which is better for delta troponin interpretation – an absolute change in troponin or a percentage change? Which delta troponin is best – 1hr, 2hr or 3hr? What are the limitations of the HEART pathway for low risk chest pain? and many more….
Podcast production, sound design & editing by Anton Helman
Written Summary and blog post by Anton Helman July, 2019
Cite this podcast as: Helman, A. McRae, A. Lang, E. Low Risk Chest Pain and High Sensitivity Troponin – A Paradigm Shift. Emergency Medicine Cases. July, 2019. https://emergencymedicinecases.com/low-risk-chest-pain-high-sensitivity-troponin. Accessed [date].
Correction July 30th, 2019: For hs-troponin T, the 2h delta to rule-out is <4ng/L and the delta to rule-in is >= 10ng/L.
Defining low risk chest pain
Patients at low risk for ACS (“low risk chest pain patients”) are those who are hemodynamically stable, are without concerning features on history or examination, and do not have immediate objective evidence of myocardial ischemia on initial ECGs and biomarker testing. Consensus guidelines further define the low risk chest pain patient as having a < 1% risk of a Major Adverse Cardiac Event (MACE) or death at ≥ 30-days follow up , a threshold below which harm caused by further testing may outweigh any clinical benefit .
Predictive value of clinical features for ACS
There is no combination of historical features that can accurately rule in or rule out ACS .
The rule for ACS presentations is: Atypical is typical .
Up to 1/3 of pts with ACS have no CP at all .
Populations most at risk for atypical presentations are women and patients with comorbidities that alter their ability to communicate (e.g. stroke, dementia) or alter their sensory perception of chest pain (e.g. diabetes, neuropathies)
The most frequent anginal equivalents in order of prevalence: SOB>weakness>unusual fatigue>sweating>dizziness
Risk factors for ACS presenting without chest pain include older patients (especially >85 years of age), women, diabetes, stroke and heart failure .
Patients with comorbidities might be at an increased risk of ACS related to diagnostic error as a result of us anchoring on their usual complications
Based on the TRAPID-AMI  and JAMA clinical exam series  the most predictive features of ACS include:
Radiation to both arms or right arm
Pain described as pressure
Associated with nausea or vomiting
Associated with sweating (especially sweating observed in the ED)
Pain came on with physical activity
Chest pain that significantly decreases the likelihood of ACS include:
Pleuritic in nature
Pain described as sharp
Pain that is fully reproducible with palpation
Note that pleuritic chest pain and pain that is reproducible with palpation have been found to be present in up to 7% of patients with ACS.
Response to nitroglycerin has no predictive value for ACS .
Severity of pain is not related to the likelihood of ACS at presentation or 30-day MACE .
Take Home:Missed ACS is more often a result of a failure to consider the diagnosis in patients with atypical symptoms rather than a failure to interpret troponin or use a clinical decision tool properly.
Predictive value of risk factors for ACS
In the ED, traditional cardiac risk factors are poor predictors of ACS in patients >40 year of age. The only traditional risk factors that have predictive value enough to alter pretest probability for ACS in the ED patient with chest pain are diabetes and family history of premature MI in male patients (not obesity, smoking, hypertension, hyperlipidemia) [11,12,].
Patients < 40 years of age without any of the traditional risk factors makes the pre-test probability of ACS very low (negative LR of 0.17) and the presence of >4 risk factors, does help predict ACS (positive LR of 7.39).
Important non-traditional risk factors, especially in young patients include: Pregnancy, chronic renal disease, HIV (especially if taking protease inhibitors), cocaine/amphetamine use, chronic steroid use and lupus.
Take Home: Classic cardiac risk factors may be more useful in shifting pretest probability for ACS in younger patients; ask about non-traditional risk factors in young patients.
Some key ACS ECG patterns and their significance: Not so low risk chest pain!
Nonspecific T-wave changes should not be ignored
In a recent retrospective study of over 2300 patients, nonspecific T-wave changes such as isolated T-wave inversion in lead III or V1 confer an increased likelihood of MACE at 30 days . Nonspecific T-wave changes are a feature of the HEART score and should not be ignored in risk stratification of chest pain patients.
De Winter’s T Waves pattern is an anterior STEMI equivalent 
A De Winter’s Waves pattern is an anterior STEMI equivalent found in 2% of patients with acute proximal LAD occlusions
Upsloping ST-Depression at J Point in leads V1 – V4 without STE
Tall, symmetric T-Wave in leads V1 – V4
STE in lead aVR +/- aVL
de Winter Waves. Note upsloping ST-depression and tall symmetric T-waves
Wellen’s Syndrome signifies a high grade LAD or Left Main coronary lesion that may present with pseudo-normalization 
Type A: While chest pain free, biphasic T waves seen in V1-V4
During chest pain, paradoxical pseudo-normalisation of ST segments may occur
Type B: Deeply inverted T-waves in leads V1 – V4 OR
Places patients at high 7-day risk for anterior STEMI
Wellen’s Type A. Note biphasic T waves.
Wellen’s Type B. Note deep inverted T-waves.
Flipped T and/or ST depression in aVL: An early sign of inferior STEMI 
An isolated flipped T-wave and/or ST depression in aVL may be an early sign of inferior STEMI, as it can represent reciprocal changes that occur prior to ST elevation, and helps to differentiate cardiac ischemia from pericarditis. However, there is a differential diagnosis of flipped T in aVL that you need to consider before you assume an impending STEMI that includes LVH with strain (T waves in same direction 1 and avL) and LBBB.
ST depression in aVL had a sensitivity 99% and specificity of 100% for inferior STEMI
84% of patients with inferior MI have reciprocal changes in aVL
Isolated T-wave inversion or ST depression in aVL may be a sign of impending inferior STEMI
Troponin facts, myths and misconceptions for low risk chest pain
Elevated troponin is not specific for myocardial infarction. One observational study of 615 patients with elevated troponin found that the overall positive predictive value for ACS was only 56% . However, troponin is an indicator of myocardial injury independent of cause.
An elevated troponin increases the risk of short-term MACE and death regardless of cause , whether from sepsis, pulmonary embolism, chronic kidney failure or heart failure .
Take Home:Avoid the terms “troponitis” or “troponemia” as they are trivializing and do not recognize this prognostic value of an elevated troponin.
Conventional vs high sensitivity troponin: Hs-troponin is not a binary test
Conventional troponin is used primarily as a binary test. Levels below the cut-off for MI require serial testing over 6-12 hours to ensure that myocardial injury is detected with adequate sensitivity. In contrast, hs-troponin assays are not used as binary tests. By definition, 50% of healthy individuals will have detectable hs-troponin concentrations. Hs-troponin assays detect much lower concentrations of serum troponin with much greater precision so that hs-troponin assays can detect clinically significant elevations and changes in troponin concentrations much sooner in an ED evaluation. The accuracy of the diagnosis of myocardial infarction is increased by analyzing the rising and falling pattern of hs-troponin rather than a binary cut-off. For example, with hs-troponin T, the 2h delta to rule-out is <4ng/L and the delta to rule-in is >= 10ng/L.
High sensitivity troponin algorithms to rule out MI and safely discharge patients from the ED with low risk chest pain
A normal ECG and a single undetectable hs-troponin drawn 3 hours or more after the onset of symptoms rules out MI at ED arrival in 1/3 of patients and portends a MACE <2% .
Two-hour serial testing rules-out MI in 60% of patients, rules-in MI in 15% of patients, leaving only 25% of patients undifferentiated after a 2-hour ED evaluation. Delta 2-hour hs-troponin <4 nanograms/liter hs-troponin T portends a MACE <2% .
Hs-troponins in combination with a 0-3 score in the HEART pathway lowers the number of low risk patients from 40% to 10% and portends a MACE <1% [23,24,30].
An absolute change in hs-troponin is recommended rather than relative percentage change to rule in acute MI
The National Academy of Clinical Biochemistry recommends using a dynamic change of 20% or more to define myocardial infarction in patients with baseline elevations in troponin . This change can be an increase or a decrease, in which increasing troponin suggests an evolving myocardial infarction, while decreasing troponin suggests a resolving myocardial infarction. The bulk of the literature suggests that an absolute delta (e.g. 10ng/L troponin T) rather than a relative change (e.g. 20%) generally performs better. Note that for hs-troponin T, the 2h delta absolute change to rule-out is <4ng/L and the delta to rule-in is >= 10ng/L.
The concern that the higher sensitivity of hs-troponin assays compared to conventional troponins are expected to result in lower specificity and over-diagnosis of ACS with increased admission rates, is unfounded in practice. Based on Canadian experience, where hs-troponins have been widely adapted, the use of high sensitivity troponins compared to conventional assays have decreased length of stay and admissions without missing any additional MIs .
Which delta hs-troponin is best – 1hr, 2hr or 3hr?
1-hour , 2-hour  and 3-hour  delta troponin algorithms have all performed well for ruling out MI and predicting >30-day MACE. Our experts recommend using the 2-hour algorithm because the 3-hour algorithm has never been shown to be superior and the 1-hour algorithm has rule-out delta and rule-in
deltas that are different by only a few nanograms per liter, which may be within the variation of the assay itself, resulting in misclassification of patients. With 2-hour delta troponins there is less risk of misclassification from assay variation.
Take Home:A single undetectable hs-troponin after 3 hours of symptom onset or a delta 2-hr hs-troponin T <4ng/L plus normal serial ECGs and a HEART score of 0-3 rules out acute MI and lowers 30-day MACE to well below 1%, a threshold below which ancillary testing may cause more harm than benefit.
Update 2021:A retrospective cohort study involving 27918 patients across 15 emergency departments demonstrated no significant difference in the incidence of 30 day acute MI or cardiac mortality when comparing patients who received one negative troponin test versus serial negative testing. Abstract
Update 2021: Prospective, observational cohort study of non-traumatic chest pain (without ST-elevation myocardial infarction), involved paramedics obtaining blood sample that is sent for troponin measurement. EMS blood samples resulted in mean potential reduction of length of stay by 72.5 +/- SD 35.7 minutes and appeared safe from a diagnostic performance perspective. Abstract
HEART Pathway is the recommended clinical decision tool for low risk chest pain
HEART pathway performs better than the TIMI score , and specifically outperforms TIMI at low risk thresholds .
HEART score with hs-troponins lowers the number of low risk patients from 40% to 10% and 30-day MACE rate lowers from 1.5% to 0.9%. If you add a second troponin at 2 or 3 hours, the MACE rate falls to 0.3% .
HEART pathway is most useful for low-medium risk patients. Patients with ECG changes or high-risk troponin findings don’t need a risk score—they need an angiogram. Patients with a normal ECG and low-risk troponin results probably don’t need a risk score, or any subsequent testing. So the real value of a risk score is for the patients with low-moderate pre-test probabilities who aren’t clearly ruled-in or ruled-out by an accelerated diagnostic pathway.
HEART pathway allows early discharge in 40% of patients compared to 18% with usual care with an NNT = 5 .
Limitations of HEART pathway:
There is variability in how people score the HEART score
HEART score has not been compared to clinical gestalt alone adequately in the literature
If HEART score were applied blindly, it would miss about 4% of MACE!
Pretest probability and gestalt are made up of components of HEART score
It is possible to have an elevated troponin level and still be considered low risk on the HEART Score
It is possible to have dynamic ECG changes and score low risk on HEART score
Patients with normal ECG and two normal hs-troponins have a very low-risk of short-term MACE, and the HEART score may overestimate their risk
Update 2020:A recent secondary analysis of the HEART Pathway (HEAR score + serial troponin testing) suggested that patients with a HEAR score of 0 or 1 may not require troponin testing to target a MACE rate less than 1%. Abstract
Is ancillary testing after the initial ED visit necessary for low risk chest pain?
“Our job in the ED is to identify ACS and not necessarily uncover anyone with coronary artery disease”
-Dr. Eddy Lang
With such a highly sensitive pathway using hs-troponins and HEART score, ancillary testing after the initial ED workup is rarely necessary. Exercise treadmill stress tests have a false positive rate as high as 80% leading to unnecessary angiograms, cardiac stents and CABG . They are poor at identifying coronary artery disease and stress test studies in low risk chest pain patients suffer from inclusion bias. Stress echo and nuclear stress testing have slightly better accuracy than treadmill exercise stress testing in identifying coronary artery disease, but have never been shown to improve patient oriented outcomes after a negative workup in the ED.
Is there a role for Cardiac Computed Tomography Angiography (CCTA) after ED visits for chest pain?
CCTA shows the presence and extent of coronary disease with reasonable accuracy. However, the use of CCTA in settings that routinely use noninvasive testing for low-to-moderate risk patients results in longer ED stays, greater resource utilization, increased invasive angiography and revascularization without substantial benefits in terms of prevention of MI or mortality [32, 33, 34, 35]. It is not clear that CCTA is any better at identifying patients at risk for death or MI compared to treadmill stress tests or nuclear stress tests. The rationale in current guidelines and editorials promoting routine CCTA use is the excellent negative predictive value of CCTA, but it is important to understand that NPV is driven largely by the risk in the population, and any test, when over-used on a low-risk population, will have excellent NPV.
The 2018 ACEP clinical policy paper on suspected non ST elevation ACS does not recommend routine use of ancillary testing prior to discharge in low risk patients in whom MI has been ruled out . They argue that limiting complex, expensive, and time-consuming testing can reduce patient cost, ED and hospital length of stay, and patient anxiety caused by unnecessary stress testing and potentially false-positive results, once adequate risk stratification and cardiac rule-out have occurred.
The American Heart Association guideline recommends that physicians work within their hospital system to establish an agreed-on approach to minimize medico-legal risk . Sit down with your cardiologists and hash this out, so that there is an agreed upon algorithm that makes sense, based on the literature. An algorithm for low risk chest pain patients that includes hs-troponin and does not include routine ancillary testing is the most reasonable approach based on the current body of literature. Efforts should be placed on patient education so they understand the risks of ancillary testing and the benefits of rational medical optimization.
Take home points for low risk chest pain and high sensitivity troponins
Missed ACS is more often a result of a failure to consider the diagnosis in patients with atypical symptoms rather than a failure to interpret troponin or use a clinical decision tool properly.
Classic cardiac risk factors may be more useful in shifting pretest probability for ACS in younger patients; ask about non-traditional risk factors in young patients.
A single undetectable hs-troponin after 3 hours of symptom onset or a delta 2-hr hs-troponin T <4ng/L plus normal serial ECGs and a HEART score of 0-3 rules out acute MI and lowers 30-day MACE to well below 1%, a threshold below which admission and/or ancillary testing may cause more harm than benefit.
An absolute change in hs-troponin is recommended rather than relative percentage change to rule in acute MI
The HEART pathway is the best clinical decision tool for ED low risk chest pain patients but has several limitations that are important to understand when applying the tool
Ancillary testing including stress testing and CCTA in low risk chest pain patients should not be done routinely during/after an ED visit
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Other FOAMed Resources on Low Risk Chest Pain and High Sensitivity Troponin
Drs. Helman and Lang have no conflicts of interest to declare. Dr. McRae received grants for his troponin research from Canadian Institutes of Health Research and as a co-investigator on an investigator-initiated, unrestricted research grant from Roche Diagnostics Canada.
Dr. Anton Helman is an Emergency Physician at North York General in Toronto. He is an Assistant Professor at the University of Toronto, Division of Emergency Medicine and the Education Innovation Lead at the Schwartz-Reisman Emergency Medicine Instititute. He is the founder, editor-in-chief and host of Emergency Medicine Cases.