This fall and winter of 2022 has seen a huge rise in pediatric respiratory illness in North America as well as increased admission for children with bronchiolitis. This was totally predictable. In a previous EM Quick Hit segment Dr. Sarah Reid warned us of the upcoming tsunami of coughing kids. There are many viruses abound: RSV, COVID, Influenza, Parainfluenza, Enterorhinovirus, Adenovirus. In Canada we’ve seen an early RSV surge in the 0-5 year old age group especially – so lots more bronchiolitis. Influenza A is far above expected levels as well, generally in the 5-11 year old age group. In this podcast Anton discusses with world expert and bronchiolitis researcher Dr. Suzanne Schuh, the challenges of the diagnosis and management of bronchiolitis during a time of crisis in pediatric emergency medicine and offers some evidence-based solutions to improving outcomes while minimizing valuable resources, as part of our ‘Best of University of Toronto EM’ series.
Podcast: Play in new window | Download (Duration: 59:56 — 54.9MB)
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Podcast production, sound design & editing by Anton Helman
Written Summary and blog post by Anton Helman, December 2022
Cite this podcast as: Helman, A. Bronchiolitis – Diagnostic Challenges and Management Pitfalls. Emergency Medicine Cases. December, 2022. https://emergencymedicinecases.com/bronchiolitis-diagnostic-challenges-management-pitfalls. Accessed June 1, 2023
Clinical assessment and diagnosis of bronchiolitis
Bronchiolitis is a clinical diagnosis based on patient age, time of year and clinical presentation. The typical patient with bronchiolitis is a child under 12 months of age who has a URTI prodrome and then develops LRTI symptoms with increased work of breathing, crackles and wheezes. It is important for clinicians and families to understand that acute symptoms generally last for approximately 10 days but can last up to 3 weeks. Neonates may present with apnea and/or cyanosis.
Clinical presentations that should alert us to either an alternative diagnosis or additional diagnosis include:
- Prolonged wheeze (≥3 weeks)
- Failure to thrive
- Recurrent feeding issues, choking with feeds
- Previous bacterial pneumonia
- Critically ill
Distinguishing bronchiolitis from asthma with URI, COVID and pneumonia
Multiple wheezing episodes at any age increases the likelihood of asthma. The diagnosis of asthma can be tentatively made in otherwise healthy children as early as 12 months of age.
A presumptive diagnosis of asthma can be made with the following criteria:
- ≥ 2episodes wheeze OR
- ED presentation needing treatment
- Reversibility of respiratory distress after therapy
- 1st time wheeze with response to therapy
- Atopy is not necessary for diagnosis
The early diagnosis of asthma is important because literature suggests that a subset of these patients will develop abnormal lung function at the age of 5 years and long term lung disease (COPD), and that this can be prevented with use of coriticosteroids. It is currently recommended that pre-school children with a presumptive diagnosis of asthma receive not only oral corticosteroids, but 3 months of inhaled corticosteroids following an acute exacerbation. Thankfully, the majority of infants with asthma improve by school age.
Pearl: A subset of pre-school children with asthma will develop chronic abnormal lung function and COPD, which can be prevented by treating acute exacerbations not only with oral corticosteroids, but 3 months of inhaled corticosteroids.
Bacterial pneumonia can be distinguished from bronchiolitis by the following:
- High fever (unusual in children with bronchiolitis)
- Toxic appearance
- Absence of wheeze
- Unilateral chest findings
Note that bacterial pneumonia is unusual under age 12 months.
COVID can cause bronchiolitis, URI and croup and should be managed similarly.
The definition and pathophysiology of bronchiolitis is variable
Complicating the approach to bronchiolitis further is the fact that the definition of bronchiolitis varies, researchers have discovered at least two different pathophysiologies, and while about 60% of bronchiolitis is caused by RSV, 20% is caused by Rhinovirus which carries a 59% risk of developing asthma.
- American Academy of Pediatrics definition of bronchiolitis: 1st episode of respiratory distress, wheeze, <24 months, poor feeding
- British Thoracic Society definition of bronchiolitis: 1st episode of respiratory distress, wheeze and/or crackles, <12 months
Indications for CXR in children with presumed bronchiolitis
Bronchiolitis is a clinical diagnosis that does not require a CXR. Routine CXR for bronchiolitis is not recommended as this often leads to unnecessary use of antibiotics. One study showed that pediatric EM physicians over-read CXRs at a rate of 5:1 compared to radiologists.
Similar to the above suggestions for when to suspect an alternative or additional diagnosis, CXR should be considered in:
- Atypical presentations- prolonged wheeze 3 weeks of more
- Suspicion of another diagnosis: FTT, recurrent feeding issues, choking with feeds, previous pneumonia
- Critically ill
Which patients with suspected bronchiolitis require viral testing?
As per Choosing Wisely Canada do not routinely test for respiratory viruses except in neonates, immunocompromised patients and those with prolonged fever and those with atypical presentations.
Identification of high risk bronchiolitis for consideration of admission
High risk bronchiolitis
- HR>180, RR 70-80+, awake persistent saturations <90%
- Age<2 months
- Prematurity <32 weeks
- Chronic lung disease
- Hemodynamically significant CHD
- Neuromuscular disease
Considerations for admission to hospital in children with bronchiolitis
In the decision of whether or not to admit a child with bronchiolitis, it is important to understand that 30% hospitalized infants receive no therapies needing hospitalization. Hospitalization for otherwise healthy children with mild bronchiolitis has been described as “expensive baby-sitting”.
- Age <2 months
- Awake sats <90%, RR>70, nasal flaring, grunting
- Behavioral changes
- Poor hydration
- Social, cultural considerations, impact on caretakers such as time off work
Considerations for ICU admission
Failure of high-flow nasal cannula (HFNC) after failure of standard oxygen therapy is usually an indication for non-invasive ventilation with CPAP and ICU admission.
Management of bronchiolitis: Volume, Oxygenation & Airway Support
Pharmacotherapy is generally ineffective in children with bronchiolitis. There is no compelling evidence that bronchodilators, steroids or epinephrine improves outcomes according to our expert. While nasal suctioning is frequently employed with the goal of improving feeding in the child with nasal obstruction, it’s efficacy is unknown. Management should concentrate on 3 things:
- Maintaining adequate volume status/feeding
- Airway support
Parental education is paramount:
- Explain the duration of illness, dynamic nature of symptoms
- Explain why drugs are ineffective
- Frequent feeding (q2h) to maintain adequate hydration
- Red flags explanation- poor feeding, behavioral change
- It is reasonable for parents to provide gentle suctioning prior to feeds (efficacy unknown)
Maintaining adequate volume status/feeding
The majority of children with bronchiolitis and volume depletion can be repleted with increasing feeds. Those that have evidence of severe dehydration or require admission to hosptial for another reason may require IV or NG volume repletion. The literature suggests equivalent outcomes and safety for IV vs NG fluid administration in children.
Oxygenation in children with bronchiolitis
Many healthy infants exhibit typical transient oxygen saturation dips during sleep. A study of children discharged from the ED with bronchiolitis showed that 62% desaturate during sleep, some with prolonged desaturations and the outcomes were the same regardless of whether desaturations were detected or not.
There is in-hospital evidence to suggest that continuous oximetry may prolong length of stay, particularly if staff react to normal transient dips in oxygen saturation or changes in heart and respiratory rates with interventions such as restarting oxygen therapy. The rationale for respiratory monitoring is to detect episodes of apnea requiring intervention; in a study of 691 infants <6 months of age, only 2.7% had documented apnea, and all had risk criteria of either a previous apneic episode or young age (<1 month or <48 weeks post-conception in premature infants). An RCT of 161 bronchiolitis inpatients at 4 U.S. hospitals randomized patients to continuous oximetry vs spot checks with vital signs and found no difference in outcomes. Continuous respiratory monitoring is indicated for high-risk patients in the ED, primarily to detect apneic episodes, but are not necessary for the vast majority of patients with bronchiolitis. Intermittent monitoring can be routinely implemented in children with mild-moderate bronchiolitis.
Pitfall: Continuous O2 saturation monitoring in stable infants with mild-moderate bronchiolitis is unnecessary and may lead to needless admissions, prolonged length of stay; spot checks are adequate.
High-flow nasal cannula are overused in children with bronchiolitis: Suggested indications for HFNC in bronchiolitis
With the increasing popularity of HFNC for children with bronchiolitis there has been a doubling of ICU care for bronchiolitis in Ontario over the past 20 years (and similar trends in the U.S), independent of age, co-morbidities and hospitalization rates. This increase in ICU admissions corresponds to the surging rate of HFNC use.
While there are no evidence based clear guidelines on the indications for HFNC in bronchiolitis, the current recommended indications according to our expert include:
- Failure of standard low-flow oxygen therapy (awake O2 saturations <90-92%)
- Increasing oxygen requirements above 40%FIO2
- Increasing lethargy
- Persistent severe respiratory distress
The main impetus for HFNC in hospital wards is to offload the ICU and to reduce ICU length of stay however the evidence does not support this outcome. Two RCTs comparing early HFNC to rescue HFNC found the same rate of ICU transfers, that 75% of patients needed no escalation of care, and that HFNC costs 16 times more than standard nasal cannula. These studies suggest that early HFNC provides costly therapy to many children who will not benefit and that HFNC should be used as rescue therapy for patients failing standard treatment rather than initiated early.
Take home messages for diagnosis and management of bronchiolitis
- Pharmacotherapy for bronchiolitis is generally ineffective and supportive therapy remains the cornerstone of management
- Supportive therapy includes 3 things: oxygenation, volume repletion and airway support
- The majority of children with bronchiolitis require only intermittent ‘spot check’ oximetry
- Use continuous oximetry selectively: marked respiratory distress, requiring supplemental oxygen
- Interpret oximetry in the clinical context and understand that children normally desaturate during sleep
- There is widespread overuse of HFNC for bronchiolitis; reserve HFNC for those who fail standard oxygen therapy as evidence suggests
- High risk bronchiolitis patients who should be considered for hospital admission include: HR>180, RR 70-80+, awake persistent saturations <90%, age <2 months, prematurity < 32 weeks, chronic lung disease, hemodynamically significant CHD, immunodeficiency, neuromuscular disease, poor hydration, social considerations
- Raita Y, Camargo CA Jr, Bochkov YA, Celedón JC, Gern JE, Mansbach JM, Rhee EP, Freishtat RJ, Hasegawa K. Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma. J Allergy Clin Immunol. 2021 Jun;147(6):2108-2117.
- Gill, PJ, Richardson, SE, Ostrow O. Testing for respiratory viruses in children: to swab or not to swab. JAMA Pediatr. 2017;171(8):798-804
- Noël KC, Fontela PS, Winters N, et al. The clinical utility of respiratory viral testing in hospitalized children: a meta-analysis. Hosp Pediatr. 2019;9(7):483-494.
- Schuh S, Babl FE, Dalziel SR, Freedman SB, Macias CG, Stephens D, Steele DW, Fernandes RM, Zemek R, Plint AC, Florin TA, Lyttle MD, Johnson DW, Gouin S, Schnadower D, Klassen TP, Bajaj L, Benito J, Kharbanda A, Kuppermann N; Pediatric Emergency Research Networks (PERN). Practice Variation in Acute Bronchiolitis: A Pediatric Emergency Research Networks Study. Pediatrics. 2017 Dec;140(6):e20170842.
- Gill PJ, Parkin P, Mahant S. Parenteral versus enteral fluid therapy for children hospitalised with bronchiolitis. Cochrane Database Syst Rev. 2020 Mar 10;2020(3):CD013552.
- Friedman JN, Rieder MJ, Walton JM; Canadian Paediatric Society, Acute Care Committee, Drug Therapy and Hazardous Substances Committee. Bronchiolitis: Recommendations for diagnosis, monitoring and management of children one to 24 months of age. Paediatr Child Health. 2014 Nov;19(9):485-98.
- Schroeder AR, Marmor AK, Pantell RH, Newman TB. Impact of pulse oximetry and oxygen therapy on length of stay in bronchiolitis hospitalizations. Arch Pediatr Adolesc Med 2004;158(6):527-30.
- Willwerth BM, Harper MB, Greenes DS. Identifying hospitalized infants who have bronchiolitis and are at high risk for apnea. Ann Emerg Med 2006;48(4):441-7.
- Hunt CE, Corwin MJ, Lister G, et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group. J Pediatr 1999;135(5):580-6.
- Principi T, Coates AL, Parkin PC, Stephens D, DaSilva Z, Schuh S. Effect of Oxygen Desaturations on Subsequent Medical Visits in Infants Discharged From the Emergency Department With Bronchiolitis. JAMA Pediatr. 2016 Jun 1;170(6):602-8.
- McCulloh R, Koster M, Ralston S, Johnson M, Hill V, Koehn K, Weddle G, Alverson B. Use of Intermittent vs Continuous Pulse Oximetry for Nonhypoxemic Infants and Young Children Hospitalized for Bronchiolitis: A Randomized Clinical Trial. JAMA Pediatr. 2015 Oct;169(10):898-904.
- Pelletier JH, Au AK, Fuhrman D, Clark RSB, Horvat C. Trends in Bronchiolitis ICU Admissions and Ventilation Practices: 2010-2019. Pediatrics. 2021 Jun;147(6):e2020039115.
- Kwon JW. High-flow nasal cannula oxygen therapy in children: a clinical review. Clin Exp Pediatr. 2020 Jan;63(1):3-7.
Drs. Helman and Schuh have no conflicts of interest to declare
excellent and very helpful . very clear guidline
A great and relevant topic, as always!
I do wonder what is Dr Schuh’s take on the other spectrum of wheezes in children, the probable asthma ones? (or, as we call it in the UK, ‘viral wheezes’).
I would love to see an episode on this and why the differences on its name in North America and the United Kingdom/different approaches.
Thank you for the ever brilliant content and material!
very informative. I recently admitted a 5month old who looked well because sats went down to 85 while asleep. so I was interested to hear that this is common. it makes sense as when I did a sleep study my sat monitor would go off as I drifted asleep and woke me up. what is the reference of the study that dr shuh mentioned?
Thanks for the podcast.
I have a question.
“A presumptive diagnosis of asthma can be made with the following criteria:
≥ 2episodes wheeze OR
ED presentation needing treatment
Reversibility of respiratory distress after therapy
1st time wheeze with response to therapy
Atopy is not necessary for diagnosis”
How is that not just viral-induced (episodic) wheeze, an entity which is well known and is thought to be different to asthma in many ways?
Can A Covid 19 positive infant who is immunocompromised have IV Remdesivir?
At what age is it safe and has anyone deployed IV Remdesivir?
Parents Smoking at home is a Risk according to CDC USA and a comment by Dr M Asuncion Mejias in ID week 2017 Oct4-8 San Diego .
He reported studies of nicotine levels in the hair of infants with RSV Bronchiolitis .
Higher levels correlated with severity as well as an array of studies of Tcell Bcell related genes suppression.
So on discharge smoking in the house needs to be stringently discouraged .
The recommendation to avoid continuous pulse ox monitoring is based on retrospective chart reviews (which have many confounders that can’t be controlled) and one well-done RCT.
However, on further look at the RCT, it was designed as a superiority trial, not a non-inferiority trial or equivalence trial. As well, their outcome was LOS, not patient outcomes. They hypothesized that spot checks would reduce LOS by 18 hours. Therefore, with a negative trial result, all you can infer is that spot checks don’t reduce LOS by 18 hours (it seems the answer is closer to 3 hours, which is probably meaningless in the real world). Their secondary outcomes that were patient centred, such as transfer to PICU, showed no difference, but these numbers were tiny (4 patients) each.
What do I conclude? Based on the evidence we have, we don’t know if spot checks vs continuous oximetry will change patient-centered outcomes. From the other articles that looked at observational data, there doesn’t seem to be any difference in harms or outcomes. Certainly, it probably makes sense to do spot checks from a patient and system perspective, but we don’t have clear evidence to support either choice.