Podcast production, editing and sound design by Anton Helman, January 2023
Podcast content, written summary & blog post by Anton Helman and Sarah Foohey, January 2023
Cite this podcast as: Helman, A. Swaminathan, Bhate, T. Healey, A. Foohey, S. Tang, JC. EM Quick Hits 45 – ETCO2, Organ Donation, Paraphimosis, Medicolegal Myths, QI Corner. Emergency Medicine Cases. January, 2023. https://emergencymedicinecases.com/em-quick-hits-january-2023/. Accessed December 7, 2023.
Value of continuous waveform quantitative end-tidal CO2 monitoring in cardiac arrest
A sudden decrease or loss of ETCO2 may indicated the need for CPR to be started
ETCO2 is an indirect assessment of quality of chest compressions (location, rate, depth); adequate chest compressions correlate with ETCO2 pressures of ≥20mmHg.
A rise of ETCO2 >20mmHg is highly specific for ROSC in patients with PEA arrest; on average, patients with ROSC after CPR had an average ETCO2 level of 25 mmHg in one meta-analysis
An up-trending ETCO2 during resuscitation suggests continuing resuscitative efforts unless there is overwhelming clinical evidence to the contrary
Confirmation of airway placement and subsequent guide for adequate delivery of breaths using BVM or supraglottic device and ventilation rates for ETT with more immediate feedback than oxygen saturation monitoring
A general “rule” is that if the ETCO2 is consistently <10mmHg for 3-5 minutes after 20 minutes of high quality CPR and resuscitative efforts, ROSC is unlikely to be achieved; however this is not a sensitive test and should be used only as an adjunctive data point in decisions of termination of resuscitation efforts
There are multiple potential confounders that can elevate or decrease ETCO2 levels (see chart below), so extreme or trending values may be more useful than unwavering mid-range levels
A sudden flattening of the ETCO2 waveform may be due to cardiac arrest, ventilator disconnection, esophageal intubation, capnography obstruction or dislodged airway device
Kodali, B. Urman, R. Capnography during cardiopulmonary resuscitation: Current evidence and future directions. J Emerg Trauma Shock. 2014 Oct-Dec: 7(4): 332-340.
Crickmer M, Drennan IR, Turner L, Cheskes S. The association between end-tidal CO2 and return of spontaneous circulation after out-of-hospital cardiac arrest with pulseless electrical activity. Resuscitation. 2021 Oct;167:76-81.
Skulec, R., Vojtisek, P. & Cerny, V. Correlation between end-tidal carbon dioxide and the degree of compression of heart cavities measured by transthoracic echocardiography during cardiopulmonary resuscitation for out-of-hospital cardiac arrest. Crit Care 23, 334 (2019).
Wang, AY. Initial end-tidal CO2 partial pressure predicts outcomes of in-hospital cardiac arrest. Am J Emerg Med. 2016 Dec;34(12):2367-2371.
Venkatesh, H. Keating, E. Can the value of end tidal CO2 prognosticate ROSC in patients coding into emergency department with an out-of-hospital cardiac arrest. Emerg Med J. 2017 Mar; 34(3): 187-189.
Paiva EF, Paxton JH, O’Neil BJ. The use of end-tidal carbon dioxide (ETCO2) measurement to guide management of cardiac arrest: a systematic review. Resuscitation. 2018;123:1–7.
Darocha T, Debaty G, Ageron FX, Podsiadło P, Hutin A, Hymczak H, Blancher M, Kosiński S, Mendrala K, Carron PN, Lamhaut L, Bouzat P, Pasquier M. Hypothermia is associated with a low ETCO2 and low pH-stat PaCO2 in refractory cardiac arrest. Resuscitation. 2022 May;174:83-90
QI Corner – Dizziness, vertigo, pre-syncope and pulmonary embolism
Recognize the margin of error in asking patients to categorize their dizziness as vertigo or presyncope and consider employing a timing and triggers-based assessment to help avoid discarding half the differential diagnosis prematurely
Stay alert to the possibility of pulmonary embolism in patients with COPD and pre-syncope or syncope even though studies have over-estimated the prevalence of PE in such populations
Make an effort to track down EMS ECG strips in patients with pre-syncope or syncope, and consider working with your hospital and EMS to develop a system that archives EMS ECGs
Couturaud F, Bertoletti L, Pastre J, Roy PM, Le Mao R, Gagnadoux F, Paleiron N, Schmidt J, Sanchez O, De Magalhaes E, Kamara M, Hoffmann C, Bressollette L, Nonent M, Tromeur C, Salaun PY, Barillot S, Gatineau F, Mismetti P, Girard P, Lacut K, Lemarié CA, Meyer G, Leroyer C; PEP Investigators. Prevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms. JAMA. 2021 Jan 5;325(1):59-68.
Saccomano SJ. Dizziness, vertigo, and presyncope: what’s the difference? Nurse Pract. 2012 Dec 10;37(12):46-52.
Thiruganasambandamoorthy V, Sivilotti M, Rowe B, et al. Prevalence of Pulmonary Embolism Among Emergency Department Patients With Syncope: A Multicenter Prospective Cohort Study. Ann Emerg Med. January 2019.
Aleva FE, Voets LWLM, Simons SO, de Mast Q, van der Ven AJAM, Heijdra YF. Prevalence and Localization of Pulmonary Embolism in Unexplained Acute Exacerbations of COPD: A Systematic Review and Meta-analysis. Chest. 2017 Mar;151(3):544-554.
Foodcourt hacks – paraphimosis, rectal prolapse, food bolus obstruction (Best of University of Toronto EM)
Consider granulated sugar dissolved in water to create an osmotic solution to reduce foreskin swelling in the management of paraphimosis
Similarly, apply granulated sugar/sugar solution to rectal prolapse tissue to reduce swelling before attempting reduction
Consider using a carbonated beverage (like Coke or Pepsi) to help manage a stable patient with esophageal food bolus obstruction when endoscopy is not immediately available, as long as the patient understands that this practice is based on case studies and not on official guidelines
Kerwat R, Shandall A, Stephenson B. Reduction of paraphimosis with granulated sugar. Br J Urol. 1998;82(5):755.
Myers JO, Rothenberger DA. Sugar in the reduction of incarcerated prolapsed bowel. Report of two cases. Dis Colon Rectum. 1991 May;34(5):416-8.
Demirel AH, Ongoren AU, Kapan M, Karaoglu N. Sugar application in reduction of incarcerated prolapsed rectum. Indian J Gastroenterol. 2007 Jul-Aug;26(4):196-7.
Baerends EP, Boeije T, Van Capelle A, Mullaart-Jansen NE, Burg MD, Bredenoord AJ. Cola therapy for oesophageal food bolus impactions a case series. Afr J Emerg Med. 2019 Mar;9(1):41-44.
Karanjia ND, Rees M. The use of Coca-Cola in the management of bolus obstruction in benign oesophageal stricture. Ann R Coll Surg Engl. 1993 Mar;75(2):94-5.
Sarkar PK. The use of Coca-Cola in the management of bolus obstruction in benign oesophageal stricture. Ann R Coll Surg Engl. 1993 Sep;75(5):377.
Organ donation do’s and don’ts
The opportunity to provide the gift of organ donation occurs rarely in our health care systems and must be preserved, even in states of surge.
3 major tasks of organ donation in the ED
Be clear about our role as EM physicians and communicate this with the family of the patient in an empathic manner e.g. “what we know now is that we have a catastrophically, very likely irreversibly injured brain in a patient who is physiologically supported, and that this injury is not reversible; we will provide physiological support until the next step in care”; avoid the terms dead and death
Physiologically support the patient (e.g. ongoing ventilatory care, hemodynamic support including monitoring end-organ perfusion, head of bed at 30 degrees, monitor neurologic status) while preserving the opportunity for them to consider organ donation
Connect with critical care team for a formal determination of prognostication – engage the critical care team who will provide ongoing support of the patient and family until a formal prognosis can be ascertained (and determine if patient meets criteria for neurologic death by examination), and during which time contact with organ donation organization can be made based on shared decision making and determination of death
None of the authors have any conflicts of interest to declare
Dr. Anton Helman is an Emergency Physician at North York General in Toronto. He is an Assistant Professor at the University of Toronto, Division of Emergency Medicine and the Education Innovation Lead at the Schwartz-Reisman Emergency Medicine Instititute. He is the founder, editor-in-chief and host of Emergency Medicine Cases.